Last data update: May 06, 2024. (Total: 46732 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Landa J[original query] |
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The epidemiology and clinical features of Balamuthia mandrillaris disease in the United States, 1974 - 2016
Cope JR , Landa J , Nethercut H , Collier SA , Glaser C , Moser M , Puttagunta R , Yoder JS , Ali IK , Roy SL . Clin Infect Dis 2018 68 (11) 1815-1822 Background: Balamuthia mandrillaris is a free-living ameba that causes rare, nearly always fatal disease in humans and animals worldwide. B. mandrillaris has been isolated from soil, dust, and water. Initial entry of Balamuthia into the body is likely via the skin or lungs. To date, only individual case reports and small case series have been published. Methods: The Centers for Disease Control and Prevention (CDC) maintains a free-living ameba (FLA) registry and laboratory. To be entered into the registry, a Balamuthia case must be laboratory-confirmed. Several sources were used to complete entries in the registry, including case report forms, CDC laboratory results, published case reports, and media information. SAS(c) version 9.3 software was used to calculate descriptive statistics and frequencies. Results: We identified 109 case reports of Balamuthia disease between 1974 and 2016. Most (99%) had encephalitis. The median age was 36 years (range 4 months to 91 years). Males accounted for 68% of the case patients. California had the highest number of case reports followed by Texas and Arizona. Hispanics constituted 55% for those with documented ethnicity. Exposure to soil was commonly reported. Among those with a known outcome, 90% of patients died. Conclusions: Balamuthia disease in the United States is characterized by a highly fatal encephalitis that affects patients of all ages. Hispanics were disproportionately affected. The southwest region of the U.S. reported the most cases. Clinician awareness of Balamuthia as a cause of encephalitis might lead to earlier diagnosis and initiation of treatment, resulting in better outcomes. |
Homogeneous subgroups of young children with autism improve phenotypic characterization in the Study to Explore Early Development
Wiggins LD , Tian LH , Levy SE , Rice C , Lee LC , Schieve L , Pandey J , Daniels J , Blaskey L , Hepburn S , Landa R , Edmondson-Pretzel R , Thompson W . J Autism Dev Disord 2017 47 (11) 3634-3645 The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. |
The Study to Explore Early Development (SEED): a multisite epidemiologic study of autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) network
Schendel DE , Diguiseppi C , Croen LA , Fallin MD , Reed PL , Schieve LA , Wiggins LD , Daniels J , Grether J , Levy SE , Miller L , Newschaffer C , Pinto-Martin J , Robinson C , Windham GC , Alexander A , Aylsworth AS , Bernal P , Bonner JD , Blaskey L , Bradley C , Collins J , Ferretti CJ , Farzadegan H , Giarelli E , Harvey M , Hepburn S , Herr M , Kaparich K , Landa R , Lee LC , Levenseller B , Meyerer S , Rahbar MH , Ratchford A , Reynolds A , Rosenberg S , Rusyniak J , Shapira SK , Smith K , Souders M , Thompson PA , Young L , Yeargin-Allsopp M . J Autism Dev Disord 2012 42 (10) 2121-40 The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal, gastrointestinal, and sociodemographic characteristics. SEED uses a case-control design with population-based ascertainment of children aged 2-5 years with an autism spectrum disorder (ASD) and children in two control groups-one from the general population and one with non-ASD developmental problems. Data from parent-completed questionnaires, interviews, clinical evaluations, biospecimen sampling, and medical record abstraction focus on the prenatal and early postnatal periods. SEED is a valuable resource for testing hypotheses regarding ASD characteristics and causes. |
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